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Accumulation of krebs cycle intermediates and over-expression of hif1alpha in tumours which result from germline fh and sdh mutations

People who have difficulty absorbing vitamin B12, such as those with Crohns disease, may benefit from B12 injections which avoid the need for absorption in the digestive tract

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Ubiquitination Ubiquitination, a reversible post-translational modification, is characterized by the covalent attachment of ubiquitin molecules to the epsilon-amino group of protein lysine residues [66, 67]