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Stem Cell Research and Therapy, 10 (1)

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In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

Rapid weight loss and a decreased appetite can sometimes lead to nutritional deficiencies, such as low vitamin B12 or iron, and cause worsening numbness, weakness, hair loss, or vision trouble