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TPE has been used as part of treatment plans for Alzheimers disease, inflammatory conditions, chronic viral infections, kidney issues, and more by reducing the protein and harmful components in the body

Importantly, it enabled discrimination between human-specific and animal-specific toxicities, such as those induced by bosentan (an endothelin receptor antagonist with known dose-dependent human hepatotoxicity) and fialuridine (an antiviral nucleoside analog that caused fatal human liver toxicity undetected in animals), thereby improving the extrapolation of preclinical findings to human outcomes

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