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Additionally, significant weight loss may unmask previously subclinical RLS or alter the severity of existing symptoms

Some studies suggest that reducing levels later in life may help to reduce the risk of cancer 48 , while other studies emphasise the importance of raising levels in the brain in order to prevent cognitive decline 49

This GLP-1R plus strategy, combining GLP-1 RAs with other hormone-based medications that target different pathways, such as amylin or GIP, may result in additive or synergistic effects that enhance weight loss and improve metabolic outcomes

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