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There was no statistical significance in the development of ION between cohorts, 1-year hazard ratio of 0.872 (95% CI: 0.6271.212), 3-year HR of 1.002 (95% CI: 0.7921.268), and 5-year HR of 0.978 (95% CI: 0.7891.211)

But it is an important consideration, given that the research published so far shows that when patients discontinue using these medications, their appetite returns, and the majority regain some or all of the weight they initially lost

10.1016/j.autrev.2025.103823 171 ZorovD