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Physiological and pathophysiological roles of NAMPT and NAD metabolism

Top panels illustrate mechanisms of action: atropine (2.1 mg) competitively antagonizes acetylcholine at muscarinic receptors to reverse cholinergic effects (e.g., bronchorrhea, bronchospasm, bradycardia), while pralidoxime (2PAM, 600 mg) reactivates acetylcholinesterase by cleaving the nerve agentenzyme bond prior to irreversible aging. Middle panels depict the dualchamber autoinjector design, which contains atropine and pralidoxime in separate compartments and delivers both drugs sequentially via a springloaded intramuscular mechanism from a single needle

doi: 10.13128/ahs-21954 7 AnutthamanP.SavkaM

Histologically, melatonin did not fully prevent immune cell accumulation in the lung parenchyma when Luzindole was present, however, the extent of infiltration remained markedly reduced compared with IL-33 alone ( Figures 2D, E )