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Phentermine has been used safely for many years, but like any medication, some patients may experience side effectsespecially when first starting treatment

When there's excessive anything in a given pathway (especially something as toxic as glutamate), the brain responds by reducing sensitivity and/or # of receptors

[DOI] [PubMed] [Google Scholar] [146].Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H, ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] Ishimoto T, Nakamichi N, Nishijima H, Masuo Y, Kato Y