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Superoxide is a major ROS produced as a by-product of oxygen metabolism and, if not neutralized, can cause a host of cellular damage [38]

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Temporal sequences of such samples may also provide information on natural hydrological changes, seasonal resource use, and human manipulation of local hydrology

However, other genetic variations associated with COPD, such as those related to alpha1-antichymotrypsin, alpha2-macroglobulin, and vitamin D-binding protein, are still under investigation (17)