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One of the main highlighted mechanisms of hypothalamic inflammation, caused by a high-calorie, high-fat diet, is the increase in the intestinal hormone glucose-dependent insulinotropic polypeptide (GIP), which promotes hypothalamic inflammation and insulin resistance [100]

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2) % of nondefecation days; 3) consecutive nondefecation days; and 4) maximum daily defecation frequency. Cutoff values were determined using maximization of the log-rank statistic