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Figure 1: A medieval urine wheel from Epiphanie Medicorum, a medical textbook printed in Nuremberg, Germany in c.1506 by Ullrich Pinder

doi:10.3390/jcm12010145 3.Perkovic V, Tuttle KR, Rossing P, et al

This situation became further unclear in 1948 when Earl Sutherland and Christan De Duve, two biochemists at Washington University School of Medicine in St Louis, detected glucagon in gastric extracts (Holst 1983